+1 for Reaper as well!
Workflow for editing, mixing, producing… is very efficient and is more or less brainless since it was designed with that in mind.
Lot of updates and new features very often, widely open on various formats (DDP export for instance).
Very flexible about your computer (Mac, PC, Linux, 32/64 bit, VST 2/3, AU, price, many updates, software protection…)
On the other side, menus (and sub-menus and sub-sub…) are longer then life, plugins UI are ugly, no synth or sampler, integrated reverb is a joke, no real integrated autotune-like tool, lot of options on the right-click menu, preference window is even longer than menus…
When working with loops or doing live performance, Live and FL Studio (Bitwig?) are better.
When writing songs with powerful synths, nice romplers, full pianos and so on, Cubase, Logic, PT… are better.
So here is my $0.02