Okay, not sure if I’m understanding what you’re hoping to do, but a standard audio interface won’t be powered, and the 1/4" jacks would be line level outputs, which could be adapted to run powered speakers, or as in your case would be connected to an input on a standard audio receiver, which would drive a regular set of non powered speakers using regular non terminated speaker wire.
Since you mentioned you have multiple speakers, if you would like to hook them up to a receiver or integrated amplifiers you would need a speaker selector. This is a box that allows 4 to 6 pairs to be simultaneously connected to one set of speaker outputs on your receiver. The speaker outputs would connect from the receiver to the box, and then out from the box to the individual speaker pairs.
The box would have on/off switches for each pair, and most importantly a transformer that would keep the impedance constant to the receiver regardless of how many pairs were selected. Pig tailing speakers into a receiver is a fast way to blow up a receiver, since the impedance drops in half by doubling the load. Most receivers will not handle much below 8 ohms, and very few 4 ohms or less. Two sets of 8 ohm speakers result in a 4 ohm load. The transformer in the speaker selector keeps the impedance steady to protect the amplifier.
So, if the receiver is shot, you need a receiver and a speaker selector box. If the interface is shot, you need that too. If it’s all shot, you could save a little using powered speakers connected to the interface.