There is a huge difference: the English keyboard is classy, understated, somewhat diffident and certainly modest.
The US keyboard, on the other hand, is brash, vulgar, mouthy and unquestionably self-interested and insular.
AS to the matter of £ and $ signs: Here are the other differences.
The UK keyboard has 1 more key than the U.S. keyboard (UK=62, US=61, on the typewriter keys)
The Alt key to the right of the space bar is replaced by an AltGr key
The # symbol is replaced by the £ symbol and a 102nd key is added next to the Enter key to accommodate the displaced #
€ is produced by AltGr + 4
@ and " are swapped
the ~ is moved to the # key, and is replaced by a ¬ symbol on the backquote (`) key; AltGr + backquote produces ¦
the key labelled "|" usually produces the "¦" symbol whilst the one labelled "¦" usually produces the "|" symbol
the \ key is moved to the left of the Z key
the Enter key spans two rows, and is narrower to accommodate the # key
Some UK keyboards do not label Backspace, Enter, Tab and Shift in words