Quick tip: I make heavy use of the soloing feature one some De-Essers. The one that lets you listen to just the S and the T sibilance. When I first listen I say ‘What frequency is annoying me’? I adjust the DS, solo the sibilance, and say ‘Ok…now and I hearing that frequency that was just bothering me a second ago’.
Another tip, since you mentioned workflow if you already have a channel strip like a Waves SSL or a multi band compressor like a C6 already loaded on your vocal strip, many of these have functions that do the exact same thing since the de-esser is really a multi band EQ. When I hear a track that needs de-essing, its not uncommon for me to grab a compressor (Like a Waves DPR 402 or a UAD voxbox) that HAS a de-essing feature built in knowing that I’ll probably use it.